The aim of the present work is the synthesis of transparent nanoparticles produced from partially fluorinated monomers. Such nanoparticles possess peculiar optical properties which make them interesting and appealing for many applications. The first stage of the work was focused on the research of synthesis methods able to lead to polymeric NPs starting from partially fluorinated monomer HFiPMA. Besides, an effective control over NPs size was pursued, testing various synthesis methods, from suspension polymerization to emulsion polymerization. Subsequently, the focus was moved to the production of transparent NPs functionalized with a fluorescent dye such as HEMA-Rh or fluorescein. Then the aim was moved to eliminate the surfactant used in previous mentioned synthesis: this was achieved through a copolymerization with a hydrophilic macromonomer such as HEMA-PEG, by means of a solvent polymerization. NPs were then obtained thanks to methods as nanoprecipitation and emulsion/solvent evaporation. During the entire work, analysis and characterization of the synthesized particles were carried on exploiting the technique of light scattering.
Il presente lavoro di tesi si propone come obiettivo la sintesi di nanoparticelle trasparenti prodotte a partire da monomeri parzialmente fluorurati. Nanoparticelle così prodotte possiedono caratteristiche ottiche peculiari che le rendono interessanti ed attraenti per numerose applicazioni. La prima fase del lavoro si è concentrata sulla ricerca di un metodo di sintesi che riuscisse a condurre a NPs polimeriche partendo dal monomero parzialmente fluorurato HFiPMA. Si è cercato inoltre di realizzare un controllo efficace delle dimensioni delle NPs ottenute, testando diversi metodi di sintesi, dalla polimerizzazione in sospensione alla polimerizzazione in emulsione. Successivamente il focus si è spostato sulla produzione di NPs trasparenti funzionalizzate con un dye fluorescente come HEMA-Rh o fluoresceina. In seguito si è puntato ad eliminare il tensioattivo utilizzato nelle sintesi sopra indicate: questo obiettivo è stato conseguito copolimerizzando un macromonomero idrofilo come l'HEMA-PEG, attraverso polimerizzazione in solvente. Le NPs sono state poi ricavate grazie a metodi quali nanoprecipitazione ed emulsione/evaporazione del solvente. Lungo il corso dell'intero lavoro, l'analisi e la caratterizzazione delle particelle sintetizzate sono state condotte sfruttando la tecnica del light scattering.
Sintesi di nanoparticelle fluorurate trasparenti
VENA, DOMENICO
2014/2015
Abstract
The aim of the present work is the synthesis of transparent nanoparticles produced from partially fluorinated monomers. Such nanoparticles possess peculiar optical properties which make them interesting and appealing for many applications. The first stage of the work was focused on the research of synthesis methods able to lead to polymeric NPs starting from partially fluorinated monomer HFiPMA. Besides, an effective control over NPs size was pursued, testing various synthesis methods, from suspension polymerization to emulsion polymerization. Subsequently, the focus was moved to the production of transparent NPs functionalized with a fluorescent dye such as HEMA-Rh or fluorescein. Then the aim was moved to eliminate the surfactant used in previous mentioned synthesis: this was achieved through a copolymerization with a hydrophilic macromonomer such as HEMA-PEG, by means of a solvent polymerization. NPs were then obtained thanks to methods as nanoprecipitation and emulsion/solvent evaporation. During the entire work, analysis and characterization of the synthesized particles were carried on exploiting the technique of light scattering.File | Dimensione | Formato | |
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2015_04_Vena.pdf
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https://hdl.handle.net/10589/107385