In this work a new procedure is presented for the reconstruction of detailed vessel and stent geometries of patients treated with Absorb BVS (Abbott Vascular), in collaboration with the Brighton and Sussex University Hospitals (Brighton, United Kingdom), allowing to obtain a reliable geometric model for fluid-dynamic simulations starting from OCT (Optical Coherence Tomography) images. The reconstruction of the geometries and the availability of OCT images in the post-operative period and after 9 months from the implant allowed the execution of preliminary analysis of clinical interest, whereby it was possible to search for differences in the distribution of TAWSS (Time-Averaged Wall Shear Stress) between the regions of interest, the analysis of the restenosis rate and the search for a correlation between TAWSS and neointima regrowth at 9 months of follow-up.
In questo lavoro viene presentata una nuova procedura per la ricostruzione delle geometrie dettagliate di vaso e stent di pazienti trattati con Absorb BVS (Abbott Vascular), in collaborazione con l’ospedale Brighton and Sussex University Hospitals (Brighton, Regno Unito), che consenta di ottenere un modello geometrico affidabile per le simulazioni fluidodinamiche partendo da immagini OCT (Optical Caherence Tomography). La ricostruzione delle geometrie e la disponibilità di immagini OCT nel post-operatorio ed a distanza di 9 mesi dall’impianto hanno permesso l’esecuzione di analisi preliminari di interesse clinico, per cui è stata possibile la ricerca delle differenze nella distribuzione di sforzo di taglio a parete mediato sull’intero ciclo cardiaco (TAWSS, Time-Averaged Wall Shear Stress) tra le regioni di interesse, l’analisi della percentuale di restenosi e la ricerca di una correlazione tra TAWSS e ricrescita di neointima a 9 mesi di follow-up.
Modelli fluidodinamici paziente-specifici di arterie coronariche trattate con stent bioriassorbibili ricostruite da immagini di tomografia a coerenza ottica
De FRANCESCO, SILVIA
2016/2017
Abstract
In this work a new procedure is presented for the reconstruction of detailed vessel and stent geometries of patients treated with Absorb BVS (Abbott Vascular), in collaboration with the Brighton and Sussex University Hospitals (Brighton, United Kingdom), allowing to obtain a reliable geometric model for fluid-dynamic simulations starting from OCT (Optical Coherence Tomography) images. The reconstruction of the geometries and the availability of OCT images in the post-operative period and after 9 months from the implant allowed the execution of preliminary analysis of clinical interest, whereby it was possible to search for differences in the distribution of TAWSS (Time-Averaged Wall Shear Stress) between the regions of interest, the analysis of the restenosis rate and the search for a correlation between TAWSS and neointima regrowth at 9 months of follow-up.File | Dimensione | Formato | |
---|---|---|---|
Tesi_DeFrancesco.pdf
non accessibile
Descrizione: Testo della tesi
Dimensione
7.27 MB
Formato
Adobe PDF
|
7.27 MB | Adobe PDF | Visualizza/Apri |
I documenti in POLITesi sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/10589/140355