This thesis work is focused on the synthesis of polymeric methyl methacrylate-based nanoparticles, and on the study of their behavior in contact with hair. In fact, polymeric nanoparticles are becoming more and more important in the cosmetic field and in the formulation of hygiene products. During this study two latex types, negative and positive, were produced with an emulsion polymerization technique and characterized. The particles produced differ in size, ranging from 100 to 1000 nm, based on the formulation used for the synthesis, and are stable and monodisperse. Adsorption in contact with human hair was therefore studied, to obtain the adsorption isotherm. The procedures used for the quantitative evaluation of the nanoparticles adsorbed on hair are two and differ for the contact method between the latex and hair. The first batch technique involves the contacting between the hair and a constant solution volume, from which continuous withdrawals are made to evaluate the adsorption. The second technique involves the passage on the hair of a continuous flow of solution in a chromatographic column packed with hair, which is constantly analyzed, allowing to evaluate the adsorption kinetics and the resistance of latex to the subsequent rinsing. Both techniques have been validated and reproducibility has been demonstrated.
Questo lavoro di tesi si concentra sulla sintesi di nanoparticelle polimeriche a base di metilmetacrilato e sullo studio del loro comportamento a contatto coi capelli umani. Le particelle polimeriche stanno infatti assumendo sempre più importanza nel campo della cosmetica e nella formulazione di prodotti per l’igiene. Durante questo studio sono state prodotte e caratterizzate due tipologie di lattici, negativi e positivi, formulati secondo una tecnica di polimerizzazione in emulsione. Le nanoparticelle prodotte differiscono per dimensione, variando da 100 a 1000 nm, in base alla formulazione usata per la sintesi, e risultano stabili e monodisperse. Ne è stato dunque studiato l’adsorbimento a contatto con i capelli umani, per ricavare delle isoterme di adsorbimento. Le procedure utilizzate per la valutazione quantitativa delle nanoparticelle adsorbite sui capelli sono due e differiscono per il metodo di contattamento tra lattice e capelli. La prima tecnica batch prevede il contattamento tra capelli e un volume di soluzione costante, da cui vengono fatti continui prelievi per valutare l’adsorbimento. La seconda tecnica prevede il passaggio sui capelli di un flusso continuo di soluzione in una colonna cromatografica impaccata coi capelli, che viene costantemente analizzato, permettendo di valutare la cinetica di adsorbimento e la resistenza del lattice al successivo risciacquo. Entrambe le tecniche sono state validate e ne è stata dimostrata la riproducibilità.
Study of adsorption of PMMA-based nanoparticles on human hair
BORELLA, OLGA MADDALENA
2017/2018
Abstract
This thesis work is focused on the synthesis of polymeric methyl methacrylate-based nanoparticles, and on the study of their behavior in contact with hair. In fact, polymeric nanoparticles are becoming more and more important in the cosmetic field and in the formulation of hygiene products. During this study two latex types, negative and positive, were produced with an emulsion polymerization technique and characterized. The particles produced differ in size, ranging from 100 to 1000 nm, based on the formulation used for the synthesis, and are stable and monodisperse. Adsorption in contact with human hair was therefore studied, to obtain the adsorption isotherm. The procedures used for the quantitative evaluation of the nanoparticles adsorbed on hair are two and differ for the contact method between the latex and hair. The first batch technique involves the contacting between the hair and a constant solution volume, from which continuous withdrawals are made to evaluate the adsorption. The second technique involves the passage on the hair of a continuous flow of solution in a chromatographic column packed with hair, which is constantly analyzed, allowing to evaluate the adsorption kinetics and the resistance of latex to the subsequent rinsing. Both techniques have been validated and reproducibility has been demonstrated.File | Dimensione | Formato | |
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https://hdl.handle.net/10589/145129