In the last years, hydrogels have become increasingly important thanks to their peculiar characteristics that make them a comfortable and versatile material. The consolidated uses linked to hydrogels are many and range in very different fields: from tissue engineering to drug delivery. It is precisely their ability to behave as a carrier for biomedical molecules, the aspect that we wanted to investigate in this study. Several procedures have been analysed to obtain hydrogels and nanogels linked to the TEMPO molecule. The choice of this molecule is linked to its numerous characteristics, but above all for its anti-inflammatory, anti-oxidant and cytoprotection capabilities, as several studies have shown. Several synthesis methodologies have been conducted to obtain different functionalizations between gel and TEMPO with the intention of obtaining a material that could be biocompatible and with biomedical properties.
Negli ultimi anni gli idrogel hanno acquisito sempre più rilevanza grazie alle loro peculiari caratteristiche che li rendono un materiale comodo e versatile. Gli usi ormai consolidati legati agli idrogel sono molteplici e spaziano in molti campi diversi: dall’ingegneria tissutale fino al drug delivery. È proprio la loro capacità di comportarsi da carrier per molecole biomediche l’aspetto che si è voluto approfondire in questo studio. Diverse procedure sono state analizzate per poter ottenere idrogel e nanogel legati alla molecola TEMPO. La scelta di tale molecola è legata alle sue numerose caratteristiche, ma soprattutto per le sue capacità anti-infiammatorie, anti-ossidanti e di citoprotezione, come hanno mostrato diversi studi. Diverse metodologie di sintesi sono state condotte per ottenere diverse funzionalizzazioni tra gel e TEMPO con l’intenzione di ottenere un materiale che possa risultare biocompatibile e con proprietà biomedicali.
Synthesis and characterization of TEMPO grafted nanogels
MALCANGI, MARIA VALERIA
2018/2019
Abstract
In the last years, hydrogels have become increasingly important thanks to their peculiar characteristics that make them a comfortable and versatile material. The consolidated uses linked to hydrogels are many and range in very different fields: from tissue engineering to drug delivery. It is precisely their ability to behave as a carrier for biomedical molecules, the aspect that we wanted to investigate in this study. Several procedures have been analysed to obtain hydrogels and nanogels linked to the TEMPO molecule. The choice of this molecule is linked to its numerous characteristics, but above all for its anti-inflammatory, anti-oxidant and cytoprotection capabilities, as several studies have shown. Several synthesis methodologies have been conducted to obtain different functionalizations between gel and TEMPO with the intention of obtaining a material that could be biocompatible and with biomedical properties.File | Dimensione | Formato | |
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https://hdl.handle.net/10589/151222